Pathogenesis of inflammatory bowel disease IBD

The inflammatory bowel disease is chronic inflammatory disease of gastrointestinal tract that include Crohn’s disease and ulcerative colitis.

Recent advances have provided substantial insight into the maintenance of mucosal immunity and the pathogenesis of inflammatory bowel disease. Cellular programs responsible for intestinal homeostasis use diverse intracellular and intercellular networks to promote immune tolerance, inflammation or epithelial restitution.

Complex interfaces integrate local host and microbial signals to activate appropriate effector programs selectively and even drive plasticity between these programs. In addition, genetic studies and mouse models have emphasized the role of genetic predispositions and how they affect interactions with microbial and environmental factors, leading to pro-colitogenic perturbations of the host commensal relationship.

Pediatric Ulcerative Colitis Fecal Calprotectin

To explore fecal calprotectin levels in pediatric ulcerative colitis (UC) in relation with the validated clinical activity index PUCAI. Methods. This retrospective study included all children with UC who had calprotectin measured and clinical data recorded for the assessment of the PUCAI at the Children’s Hospital of Helsinki from December 2005 to January 2012, most samples being from the three recent years. Diagnosis of UC was based on typical clinical presentation as well as upper and lower endoscopy

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